Oct 26, 2021 · The codeine in Promethazine VC with Codeine can cause newborns to experience withdrawal syndrome, which is life-threatening for infants. Withdrawal syndrome is a condition that develops when Promethazine VC with Codeine crosses through the placenta and causes the unborn baby to become dependent on the medication. Generic Name (S): codeine-guaifenesin. Warnings: This medication has a risk for abuse and addiction, which can lead to overdose and death. This medication may also cause severe, possibly fatal ...Promethazine. Codeine is an effective pain reliever; however, it is addictive, may cause constipation, and its pain-relieving effects vary markedly between individuals. Codeine should only be used for pain relief... more. Promethazine may be used to relieve allergy symptoms and nausea. Sedation is the main side effect and it may interact with ... Promethazine is an antihistamine that relieves watery eyes, itchy eyes /nose/throat, runny nose, and sneezing. Codeine is an opioid cough suppressant ( antitussive) that affects a certain part...If you are 65 or older, use promethazine and codeine with care. You could have more side effects. The chance of very bad side effects may be higher in children. This may be more likely to happen in children who have breathing problems. Deadly breathing problems have happened with the use of codeine in some children.Aug 15, 2018 · 5.1 Addiction, Abuse, and Misuse. Promethazine with Codeine Oral Solution contains codeine, a Schedule V controlled substance. As an opioid, Promethazine with Codeine Oral Solution exposes users to the risks of addiction, abuse, and misuse [see DRUG ABUSE AND DEPENDENCE (9)], which can lead to overdose and death [seeOVERDOSAGE (10)]. The most frequently reported codeine-containing medicines in the cases were acetaminophen with codeine used for pain, and promethazine with codeine (with or without phenylephrine) used for cough ... Promethazine 6.25 mg/ Codeine 10 mg per 5 mL: Average effective dose: 5 mL orally every 4 to 6 hours as needed. Maximum dose: 30 mL (promethazine 37.5 mg; codeine: 60 mg) in 24 hours. Comments: Liquid preparations should be measured with an accurate milliliter measuring device. Uses: Temporary relief of coughs and upper respiratory symptoms ...Dec 13, 2022 · severe nervous system reaction--very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors, feeling like you might pass out. Side effects such as confusion and severe drowsiness may be more likely in older adults. Common promethazine side effects may include: drowsiness, dizziness; ringing in your ears; Lean is a very sweet drink that blends soda with cough syrup containing codeine. Some formulas also add candy or sweetening syrup. Users may also mix in promethazine, which is an antihistamine ...Use Caution/Monitor. Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. Interaction more likely in certain predisposed pts. only. codeine and protriptyline both increase sedation. Use Caution/Monitor. promethazine and protriptyline both increase QTc interval.Codeine (3-methylmorphine) is an alkaloid prepared from the methylation of morphine derived from poppy seeds ( Papaver somniferum) [ 1 ]. It is used to manage mild to moderate pain, including chronic cancer pain, and has antitussive, antistress, and antidiarrheal properties [ 2, 3, 4 ]. In the body, a small amount of codeine is metabolized to ...Aug 1, 2023 · Promethazine is an antihistamine. It works by preventing the effects of a substance called histamine, which is produced by the body. Histamine can cause itching, sneezing, runny nose, and watery eyes. It can sometimes close up the bronchial tubes (air passages of the lungs) and make breathing difficult. Codeine belongs to the group of medicine ... Aug 1, 2023 · Promethazine is an antihistamine. It works by preventing the effects of a substance called histamine, which is produced by the body. Histamine can cause itching, sneezing, runny nose, and watery eyes. It can sometimes close up the bronchial tubes (air passages of the lungs) and make breathing difficult. Codeine belongs to the group of medicine ... See full list on drugs.com Aug 1, 2023 · Descriptions. Promethazine and codeine combination is used to relieve cough, runny or stuffy nose, sneezing, or other symptoms caused by allergies or the common cold. Promethazine is an antihistamine. It works by preventing the effects of a substance called histamine, which is produced by the body. Histamine can cause itching, sneezing, runny ... a liquid that you swallow – this contains 25mg of codeine in a 5ml spoonful. The usual dose of codeine is 15mg to 60mg. adults – one or two 30mg tablets, taken every 4 hours, up to a maximum of 8 tablets (240mg) in 24 hours. children (aged 12 to 17 years) – one or two 30mg tablets (or one or two 5ml spoonfuls of liquid), taken every 6 hours.codeine. Used for Pain. Codeine is an opioid pain medication that's taken by mouth and used to treat mild-to-moderate pain. Common side effects of codeine include constipation, itching, sleepiness, and dizziness. It's typically not a first-choice pain medication because it can lead to more serious harm, such as slowed breathing and addiction.Sep 14, 2022 · Promethazine Dosage and Administration Administration. Administer orally, rectally, or by deep IM injection. Also administered by IV injection. However, FDA states that deep IM injection is the preferred method for administration of promethazine hydrochloride injection because of risks associated with IV administration (see Warnings Regarding Parenteral Administration under Boxed Warning). May 5, 2020 · Promethazine with Codeine Oral Solution is a combination of codeine, an opioid agonist; and promethazine, a phenothiazine, indicated for the temporary relief of cough and upper respiratory symptoms associated with allergy or the common cold in patients 18 years of age and older. Schedule 5 (V) Drugs. The drug has a low potential for abuse relative to the drugs in schedule 4. The drug has a currently accepted medical use in treatment in the United States. Lean, also known as purple drank, purp, sizzurp, syrup, wock or oil, and several other names, is a recreational drug beverage, prepared by mixing prescription strength cough or cold syrup containing codeine and promethazine with a soft drink. The beverage originated in Houston and is popular in hip hop culture, especially within the Southern ... Codeine cough suppressants like promethazine/codeine should only be an option for short-term use — and only in adults. This type of cough syrup is available by prescription. However, it is a controlled substance and habit-forming. Best cough medicine for kidsCodeine is used to relieve mild to moderate pain. It belongs to the group of medicines called narcotic analgesics (pain medicines). This medicine acts on the central nervous system (CNS) to relieve pain. When codeine is used for a long time, it may become habit-forming, causing mental or physical dependence. However, people who have continuing ...Sep 20, 2012 · Codeine is used to relieve mild to moderately severe pain, and it belongs to the drug class of opioid analgesics. Codeine has also been prescribed to prevent coughing, though the antitussive administration is most often in liquid formulations and in conjunction with other medications. ( 1, 2) The hepatic CYP2D6 enzyme metabolizes a quarter of ... Oxycodone (OxyContin, Roxicodone, Oxaydo, Xtampza ER) and codeine are both narcotic pain relievers. Both are also used as cough suppressants similar to morphine and hydrocodone. Both are potentially addictive and cause withdrawal symptoms. Similar side effects of oxycodone and codeine include lightheadedness, dizziness, sedation, nausea, vomiting, constipation, dry mouth, itching, and rash.cough. darkened urine. darkening of the skin. diarrhea. difficult or trouble breathing. difficulty swallowing. dizziness. dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position. fainting.Codeine (3-methylmorphine) is an alkaloid prepared from the methylation of morphine derived from poppy seeds ( Papaver somniferum) [ 1 ]. It is used to manage mild to moderate pain, including chronic cancer pain, and has antitussive, antistress, and antidiarrheal properties [ 2, 3, 4 ]. In the body, a small amount of codeine is metabolized to ...A total of 486 drugs are known to interact with codeine / guaifenesin : 122 major drug interactions (477 brand and generic names) 361 moderate drug interactions (1496 brand and generic names) 3 minor drug interactions (7 brand and generic names) A total of 748 drugs are known to interact with codeine / promethazine : 181 major drug interactions ...Promethazine HCl and Codeine Phosphate Oral Solution exposes patients and other users to the risks of opioid addiction, abuse, and misuse, which can lead to overdose and death. Reserve Promethazine HCl and Codeine Phosphate Oral Solution for use in adult patients for whom the In the early 1990s, several studies reported the misuse of codeine and promethazine hydrochloride cough syrup. Since then, the combination of this pharmaceutical, together with sprite or alcohol, known on the streets as "purple drank" or "lean", has become a popular drug among rap singers who promot …Sep 14, 2018 · Codeine is a prescription opioid, which is used as a pain reliever, and promethazine is an antihistamine. Both drugs have sedative effects and can produce feelings of drowsiness, mild euphoria and ... Jul 20, 2021 · Codeine is a drug in some prescription pain medicines. It is in the class of drugs known as opioids, which refers to any synthetic, semisynthetic, or natural drug that has morphine-like properties. Codeine overdose occurs when someone takes more than the normal or recommended amount of this medicine. This can be by accident or on purpose. This ... Apr 13, 2023 · When codeine is used to reduce coughing, it works by decreasing the activity in the part of the brain that causes coughing. Codeine is also available in combination with acetaminophen (Capital and Codeine, Tylenol with Codeine), aspirin, carisoprodol, and promethazine and as an ingredient in many cough and cold medications. Codeine and promethazine es una medicina combinada se usa para el tratamiento de los síntomas del resfrío o alergias como nariz mocosa, estornudos, y tos. Codeine and promethazine contiene una medicina opioide (narcótico) para la tos, y puede crear hábito. . Codeine and promethazine puede también usarse para fines no... Find patient medical information for promethazine oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. ... (such as codeine, hydrocodone), ... A total of 486 drugs are known to interact with codeine / guaifenesin : 122 major drug interactions (477 brand and generic names) 361 moderate drug interactions (1496 brand and generic names) 3 minor drug interactions (7 brand and generic names) A total of 748 drugs are known to interact with codeine / promethazine : 181 major drug interactions ...Generic name: codeine / promethazine systemic Drug class: upper respiratory combinations. For consumers: dosage, interactions, side effects. For professionals: Prescribing Information. Expand current row for information about Hycodan Hycodan: 8.5 Lean, also known as purple drank, purp, sizzurp, syrup, wock or oil, and several other names, is a recreational drug beverage, prepared by mixing prescription strength cough or cold syrup containing codeine and promethazine with a soft drink. The beverage originated in Houston and is popular in hip hop culture, especially within the Southern ... Phenergan with Codeine (promethazine and codeine) is a combination of an antihistamine, sedative, anti-nausea drug, cough suppressant, pain reliever, and cough suppressant used to treat common cold symptoms and cough. Common side effects of Phenergan with Codeine include dizziness, restlessness, inability to sleep, palpitations, and changes in muscle tone and more. Withdrawal symptoms may ...Sep 20, 2012 · Codeine is used to relieve mild to moderately severe pain, and it belongs to the drug class of opioid analgesics. Codeine has also been prescribed to prevent coughing, though the antitussive administration is most often in liquid formulations and in conjunction with other medications. ( 1, 2) The hepatic CYP2D6 enzyme metabolizes a quarter of ... Promethazine with codeine syrup is indicated for the temporary relief of coughs and upper respiratory symptoms associated with allergy or the common cold. CONTRAINDICATIONS. The combination of promethazine hydrochloride and codeine phosphate is contraindicated in pediatric patients less than 6 years of age, because the combination may cause ...Schedule 5 (V) Drugs. The drug has a low potential for abuse relative to the drugs in schedule 4. The drug has a currently accepted medical use in treatment in the United States. Codeine belongs to the group of medicines called narcotic analgesics (pain medicines). It acts on the central nervous system (CNS) to relieve pain. Phenylephrine is a decongestant. It works by narrowing the blood vessels and leads to the clearing of nasal congestion. Promethazine is an antihistamine.Aug 6, 2023 · Hycofenix, Rezira (hydrocodone, pseudoephedrine, guaifenesin) Tussionex, Pennkinetic, Vituz (hydrocodone, chlorpheniramine, pseudoephedrine) Generic combinations of hydrocodone and homatropine. Giving prescription cough medicines to kids or teens is dangerous. They can slow their breathing to dangerous levels and can even be fatal. Codeine, an opioid analgesic, was originally approved in the US in 1950 and is a drug used to decrease pain by increasing the threshold for pain without impairing consciousness or altering other sensory functions. Opiates such as codeine are derived from the poppy plant, Papaver somniferum (Papaveraceae). Codeine is utilized as a central ...Promethazine 6.25 mg/ Codeine 10 mg per 5 mL: Average effective dose: 5 mL orally every 4 to 6 hours as needed. Maximum dose: 30 mL (promethazine 37.5 mg; codeine: 60 mg) in 24 hours. Comments: Liquid preparations should be measured with an accurate milliliter measuring device. Uses: Temporary relief of coughs and upper respiratory symptoms ...See full list on drugs.com The most frequently reported codeine-containing medicines in the cases were acetaminophen with codeine used for pain, and promethazine with codeine (with or without phenylephrine) used for cough ...Promethazine is an antihistamine that relieves watery eyes, itchy eyes /nose/throat, runny nose, and sneezing. Codeine is an opioid cough suppressant ( antitussive) that affects a certain part...Promethazine/codeine is an inexpensive drug used as a cough suppressant, a decongestant, and an antihistamine. It helps to stop or reduce coughing and congestion. It is more popular than comparable drugs. Promethazine/codeine is only available as a generic drug; all brands have been discontinued. Apr 15, 2023 · Codeine and morphine were detected in the milk of both subjects with peak codeine levels in milk occurring 1 hour after the dose. The peak codeine milk level was 455 mcg/L in the first subject and about 450 to 550 mcg/L in the second. The half-life of codeine in breastmilk was 2.5 hours. Morphine milk levels were 16 mcg/L and 9 mcg/L 1 hour ... Promethazine is an antihistamine that relieves watery eyes, itchy eyes /nose/throat, runny nose, and sneezing. Codeine is an opioid cough suppressant ( antitussive) that affects a certain part...Generic Name (S): codeine-guaifenesin. Warnings: This medication has a risk for abuse and addiction, which can lead to overdose and death. This medication may also cause severe, possibly fatal ... Jun 23, 2020 · Long-term use of opioid medication may affect fertility (ability to have children) in men or women. It is not known whether opioid effects on fertility are permanent. Common side effects include ... Descriptions. Acetaminophen and codeine combination is used to relieve mild to moderate pain. Acetaminophen is used to relieve pain and reduce fever in patients. It does not become habit-forming when taken for a long time. But acetaminophen may cause other unwanted effects when taken in large doses, including serious liver damage.Codeine is a drug in some prescription pain medicines. It is in the class of drugs known as opioids, which refers to any synthetic, semisynthetic, or natural drug that has morphine-like properties. Codeine overdose occurs when someone takes more than the normal or recommended amount of this medicine. This can be by accident or on purpose.Generic name: promethazine hydrochloride and codeine phosphate Dosage form: oral solution Drug class: Upper respiratory combinations Medically reviewed by Drugs.com. Last updated on Jan 1, 2022. On This Page Indications and Usage Dosage and Administration Dosage Forms and Strengths Contraindications Warnings and PrecautionsPromethazine Codeine is a combination medicine used to treat allergy symptoms such as runny nose, sneezing, and cough. Promethazine with Codeine contains an opioid (narcotic) cough medicine, and may be habit-forming. Promethazine with Codeine may also be used for purposes not listed in this medication guide. Promethazine with Codeine side effectsFeb 1, 2023 · Acetaminophen/codeine oral solution. Each 5 mL of acetaminophen/codeine solution contains 12 mg of codeine and 120 mg of acetaminophen. The typical dose is 15 mL by mouth every 4 hours as needed. Do not take more than 3,000 mg to 4,000 mg of acetaminophen within a 24-hour period. Phenergan with Codeine (promethazine and codeine) is a combination of an antihistamine, sedative, anti-nausea drug, cough suppressant, pain reliever, and cough suppressant used to treat common cold symptoms and cough. Common side effects of Phenergan with Codeine include dizziness, restlessness, inability to sleep, palpitations, and changes in muscle tone and more. Withdrawal symptoms may ...Aug 6, 2023 · Hycofenix, Rezira (hydrocodone, pseudoephedrine, guaifenesin) Tussionex, Pennkinetic, Vituz (hydrocodone, chlorpheniramine, pseudoephedrine) Generic combinations of hydrocodone and homatropine. Giving prescription cough medicines to kids or teens is dangerous. They can slow their breathing to dangerous levels and can even be fatal. Feb 13, 2023 · Codeine is a medication used in the management and treatment of chronic pain. It is in the opioid class of medications. This activity outlines the indications, action, and contraindications for codeine as a valuable agent in treating chronic pain and off-label use in cough, persistent diarrhea, and restless leg syndrome. In addition, this activity will highlight the mechanism of action ... Schedule 5 (V) Drugs. The drug has a low potential for abuse relative to the drugs in schedule 4. The drug has a currently accepted medical use in treatment in the United States. In the early 1990s, several studies reported the misuse of codeine and promethazine hydrochloride cough syrup. Since then, the combination of this pharmaceutical, together with sprite or alcohol, known on the streets as "purple drank" or "lean", has become a popular drug among rap singers who promot … Codeine is a drug in some prescription pain medicines. It is in the class of drugs known as opioids, which refers to any synthetic, semisynthetic, or natural drug that has morphine-like properties. Codeine overdose occurs when someone takes more than the normal or recommended amount of this medicine. This can be by accident or on purpose. This ...Schedule 5 (V) Drugs. The drug has a low potential for abuse relative to the drugs in schedule 4. The drug has a currently accepted medical use in treatment in the United States.Promethazine Dosage and Administration Administration. Administer orally, rectally, or by deep IM injection. Also administered by IV injection. However, FDA states that deep IM injection is the preferred method for administration of promethazine hydrochloride injection because of risks associated with IV administration (see Warnings Regarding Parenteral Administration under Boxed Warning).Uses for Phenergan w/Codeine. Promethazine and codeine combination is used to relieve cough, runny or stuffy nose, sneezing, or other symptoms caused by allergies or the common cold. Promethazine is an antihistamine. It works by preventing the effects of a substance called histamine, which is produced by the body.Promethazine Codeine is a combination medicine used to treat allergy symptoms such as runny nose, sneezing, and cough. Promethazine with Codeine contains an opioid (narcotic) cough medicine, and may be habit-forming. Promethazine with Codeine may also be used for purposes not listed in this medication guide. Promethazine with Codeine side effectsAug 15, 2018 · 5.1 Addiction, Abuse, and Misuse. Promethazine with Codeine Oral Solution contains codeine, a Schedule V controlled substance. As an opioid, Promethazine with Codeine Oral Solution exposes users to the risks of addiction, abuse, and misuse [see DRUG ABUSE AND DEPENDENCE (9)], which can lead to overdose and death [seeOVERDOSAGE (10)]. The codeine in Promethazine VC with Codeine can cause newborns to experience withdrawal syndrome, which is life-threatening for infants. Withdrawal syndrome is a condition that develops when Promethazine VC with Codeine crosses through the placenta and causes the unborn baby to become dependent on the medication.What is codeine and promethazine? Codeine and promethazine is a combination medicine used to treat cold or allergy symptoms such as runny nose, sneezing, and cough. Codeine and promethazine contains an opioid (narcotic) cough medicine, and may be habit-forming. Codeine and promethazine may also be used for purposes not listed in this medication ...Jan 20, 2021 · Typical dosing for Robitussin AC (guaifenesin / codeine) Adults and children over 12 years old: The typical dose is 2 teaspoonfuls (10 mL) by mouth every 4 hours as needed. Children between 6 and 12 years old: The typical dose is 1 teaspoonful (5 mL) by mouth every 4 hours as needed. Children under 6 years old: Speak with your child's provider. codeine/promethazine systemic. Drug class: upper respiratory combinations. Codeine/promethazine systemic is used in the treatment of: Cough; codeine/pseudoephedrine systemic. Brand names: Cycofed, Nucodine, Codar D, Nucofed, EndaCof-DC Drug class: upper respiratory combinations. Codeine/pseudoephedrine systemic is used in the treatment of:For all patients taking this drug: This drug has an opioid drug in it. Opioid drugs can put you at risk for addiction, abuse, and misuse. Misuse or abuse of this drug can lead to overdose and death. If you have questions, talk with your doctor. This drug may cause very bad and sometimes deadly breathing problems.Phenergan is also found in combination with other medications such as phenylephrine (Prometh Hydrochloride), codeine (Prometh VC), or dextromethorphan (Promethazine DM) What is Phenergan? Phenergan belongs to a group of drugs called phenothiazines. It works by changing the actions of chemicals in your brain. Promethazine also acts as an ...Tramadol and codeine are both opioids or opiates used to control pain. Codeine is also used as a cough medication. Both codeine and tramadol are habit forming. The most frequent side effects of codeine and tramadol include lightheadedness, dizziness, nausea, vomiting, shortness of breath, sedation, allergic reactions, constipation, abdominal pain, rash, itching, and addiction.
Promethazine is an antihistamine that relieves watery eyes, itchy eyes /nose/throat, runny nose, and sneezing. Codeine is an opioid cough suppressant ( antitussive) that affects a certain part... . Tulsa
Promethazine with Codeine Oral Solution is a combination of codeine, an opioid agonist; and promethazine, a phenothiazine, indicated for the temporary relief of cough and upper respiratory symptoms associated with allergy or the common cold in patients 18 years of age and older.May 5, 2020 · Promethazine with Codeine Oral Solution is a combination of codeine, an opioid agonist; and promethazine, a phenothiazine, indicated for the temporary relief of cough and upper respiratory symptoms associated with allergy or the common cold in patients 18 years of age and older. Jan 27, 2023 · Promethazine VC with Codeine Oral Solution is a combination of codeine, an opioid agonist; promethazine, a phenothiazine; and phenylephrine, an alpha-1 adrenergic receptor agonist, indicated for the temporary relief of cough and upper respiratory symptoms, including nasal congestion, associated with allergy or the common cold in patients 18 years of age and older. Promethazine is a prescription cold medication used to treat various conditions, including nausea and vomiting. Codeine is a naturally occurring opiate that relieves pain. They are combined in promethazine-codeine cough syrup, a prescription medication used to alleviate symptoms of allergies or the common cold.Promethazine Codeine is a combination medicine used to treat allergy symptoms such as runny nose, sneezing, and cough. Promethazine with Codeine contains an opioid (narcotic) cough medicine, and may be habit-forming. Promethazine with Codeine may also be used for purposes not listed in this medication guide. Promethazine with Codeine side effectsPromethazine Codeine is a combination medicine used to treat allergy symptoms such as runny nose, sneezing, and cough. Promethazine with Codeine contains an opioid (narcotic) cough medicine, and may be habit-forming. Promethazine with Codeine may also be used for purposes not listed in this medication guide. Promethazine with Codeine side effectsMay 5, 2020 · Promethazine with Codeine Oral Solution is a combination of codeine, an opioid agonist; and promethazine, a phenothiazine, indicated for the temporary relief of cough and upper respiratory symptoms associated with allergy or the common cold in patients 18 years of age and older. Physical effects. Codeine taken at high doses could produce the following effects that can last 3-5 hours: drowsiness. headaches. slowed breathing. nausea and vomiting. smaller (constricted) pupils. feeling heavy in the arms and legs. severe itching or warm/hot sensation on the skin.Each 5 mL (one teaspoonful), for oral administration contains: Promethazine hydrochloride 6.25 mg; codeine phosphate 10 mg. Alcohol 7%. Inactive Ingredients: Ascorbic acid, citric acid, FD&C ... Codeine: Narcotic analgesics, including codeine, exert their primary effects on the central nervous system and gastrointestinal tract. The analgesic ...Aug 29, 2023 · Codeine cough suppressants like promethazine/codeine should only be an option for short-term use — and only in adults. This type of cough syrup is available by prescription. However, it is a controlled substance and habit-forming. Best cough medicine for kids -Codeine (an opiate that treats pain and coughs) -Hydrocodone (an opiate used to treat moderate to severe pain) -Phenacetin (an analgesic that's not used much anymore)Aug 27, 2009 · Each 5 mL (one teaspoonful), for oral administration contains: Promethazine hydrochloride 6.25 mg; codeine phosphate 10 mg. Alcohol 7%. Inactive Ingredients: Ascorbic acid, citric acid, FD&C ... Codeine: Narcotic analgesics, including codeine, exert their primary effects on the central nervous system and gastrointestinal tract. The analgesic ... a liquid that you swallow – this contains 25mg of codeine in a 5ml spoonful. The usual dose of codeine is 15mg to 60mg. adults – one or two 30mg tablets, taken every 4 hours, up to a maximum of 8 tablets (240mg) in 24 hours. children (aged 12 to 17 years) – one or two 30mg tablets (or one or two 5ml spoonfuls of liquid), taken every 6 hours.5.1 Addiction, Abuse, and Misuse. Promethazine with Codeine Oral Solution contains codeine, a Schedule V controlled substance. As an opioid, Promethazine with Codeine Oral Solution exposes users to the risks of addiction, abuse, and misuse [see DRUG ABUSE AND DEPENDENCE (9)], which can lead to overdose and death [seeOVERDOSAGE (10)].Oct 26, 2021 · The codeine in Promethazine VC with Codeine can cause newborns to experience withdrawal syndrome, which is life-threatening for infants. Withdrawal syndrome is a condition that develops when Promethazine VC with Codeine crosses through the placenta and causes the unborn baby to become dependent on the medication. .